This report outlines a 3-year program to upgrade the knowledge platform for managing water resources in Central Asia. Its ultimate purpose is to enhance the ability of all countries to engage in evidenced- based dialogue on water and energy management. It focuses on regional actions, linking all five countries plus Afghanistan, but recognizes the essential role of national initiatives. It covers the core elements of a modern decision support system and, based on extensive consultations, supports a change in accessing, developing, and sharing information and analysis. The intended outcomes of the road map are to: (i) establish a knowledge platform that is accepted by countries as a basis for cooperative actions; (ii) enhance capacity and knowledge sharing at the national and regional levels; and (iii) directly improve management of water at national and transboundary scales.